The earliest traces of human activity in the place of Nisa belong to 2-4 thousand BC. In 1 thousand BC, there already existed a fairly large settled settlement. Nisa was declared a World Heritage Site by UNESCO in 2007. Nisa is described by some as one of the first capitals of the Parthians. It was founded by Arsaces I (reigned c. 250 BC – 211 BC), and was reputedly the royal necropolis of the Parthian kings.
Old Nissa (formerly Mitridatkert) is of high interest to travelers. It is a strong fortress in a form of an irregular pentagon (14 hectares) and one unapproachable bastion. The fortifications are 9 meters thick foundation and were strengthened by 43 rectangular towers.